What is Tetra Curcumin?

Contains Tetrahydro curcuminoids, the bio-active (hydrogenated) metabolite of curcumin from Curcuma longa.

Unlike curcumin, which is yellow in color, tetrahydro curcumin is white.

Tetrahydro curcumin C3 Reduct™ in this product has a purity of 98% and is patented and manufactured by Sabinsa Corporation, USA.

BioPerine is a standardized extract of Piper nigrum, manufactured by Sabinsa Corporation USA.  It significantly increases the bioavailability of Tetrahydro curcuminoids.

Health benefits

• Curcumin is hardly absorbed in the intestines¹
• Tetrahydro curcumin (tetrahydro curcuminoids) is significantly superior to curcumin both in terms of bio-absorption and anti-inflammatory effect, requiring much lower doses but with a much more concentrated and diversified effect², also potentiated by the association with BioPerine.
• Anti-cancer activity superior to curcumin ^{3, 4}
• It has protective effects against diabetes and vascular dysfunction by relieving oxidative stress^5,6
• Anti-inflammatory activity superior to curcumin⁷
• Anti-inflammatory activity at the brain level with positive effects against Alzheimer’s and Parkinson’s as well as against the oxidative stress induced by Glutamate in the cells of the hippocampus ^{8,9, 10}
• Protective effect in neuropathy by improving the conductivity of motor nerves¹¹

Tetra Curcumin C3 composition

Ingredients / vegetable capsule:

C3 Reduct R is a registered trademark of Sabinsa Corp, USA

BioPerine R is a registered trademark of Sabinsa Corp, USA

Does not contain: artificial colors, preservatives or sweeteners, dairy, eggs, gluten, soy, wheat, corn, yeast, nuts, or GMOs.

Suitable for vegans and vegetarians.

Net weight e = 21.72g.

Recommended dose (adults): 1 capsule 1-2 times a day.

Warnings and precautions:

• Consult your health care professional before use if you are pregnant or nursing.
• Consult your health care professional if you are taking other medications or health products, as pepper may alter or enhance their effectiveness.
• Do not exceed the recommended dose for daily consumption without the specialist’s recommendation.
• Dietary supplements do not replace a varied and balanced diet and a healthy lifestyle.

Provita Nutrition and Health Inc., Vancouver, 1102-1225 Kingsway Ave, Port Coquitlam, BC, Canada V3C 1S2

1. Adrian L Lopresti, The Problem of Curcumin and Its Bioavailability: Could Its Gastrointestinal Influence Contribute to Its Overall Health-Enhancing Effects? 2018 American Society for Nutrition, Adv Nutr 2018;9:41–50
2. Zhen-Biao Zhang et al., Curcumin’s Metabolites, Tetrahydrocurcumin and Octahydrocurcumin, Possess Superior Anti-inflammatory Effects in vivo Through Suppression of TAK1-NF-κB Pathway, Front. Pharmacology Volume 9 – 2018
3. Ching-Shu Lai et  al. The Cancer Chemopreventive and Therapeutic Potential of Tetrahydrocurcumin, Biomolecules 2020, 10, 831
4. Anqi Zeng et al. Tetrahydrocurcumin regulates the tumor immune microenvironment to inhibit breast cancer proliferation and metastasis via the CYP1A1/NF-κB signaling pathway, Cancer Cell International, Article number: 12 (2023)
5. Namareoung, S. et al.: Naun.-Schmied. Arch. Pharmacol.,383, 519 (2011);
6. Kartileksan, K. et al.: J. Func. Foods, 2, 134 (2009)
7. Hui-Wen Lin et al. Suppressive Effect of Tetrahydrocurcumin on Pseudomonas aeruginosa Lipopolysaccharide-Induced Inflammation by Suppressing JAK/STAT and Nrf2/HO-1 Pathways in Microglial Cells, Oxidative Medicine and Cellular Longevity, Article ID 4978556  Hindawi 2022
8. Slavica Josifovska et al. Positive Tetrahydrocurcumin-Associated Brain-Related Metabolomic Implications, Molecules. 2023 May; 28(9): 3734
9. Chang-Hyun Park et al. Neuroprotective Effects of Tetrahydrocurcumin against Glutamate-Induced Oxidative Stress in Hippocampal HT22 Cells, Molecules. 2020 Jan; 25(1): 144
10. Yu Xiao et al. Tetrahydrocurcumin ameliorates Alzheimer’s pathological phenotypes by inhibition of microglial cell cycle arrest and apoptosis via Ras/ERK signaling, Biomedicine & Pharmacotherapy, Volume 139, July 2021, 111651
11. Greeshma et al. Tetrahydrocurcumin exerts protective effect on vincristine induced neuropathy: Behavioral, biochemical, neurophysiological and histological evidence, Chemico-Biological Interactions, Volume 238, 5 August 2015, Pages 118-128